Forskningsprogram i autismespektrum-forstyrrelser

Programbeskrivelse

Forskningsprogrammet inkluderer forskning inden for autismeområdet i såvel børne- og ungebefolkningen som hos voksne. Det drejer sig især om forskning inden for ætiologi, epidemiologi, forløb samt outcome. Der er både tale om registerbaserede studier, spørgeskemaundersøgelser og kliniske studier.

Ligeledes laves de sidste analyser i et genetisk studie af genetiske abnormiteter (påvist ved aCGH) i en klinisk population henvist på mistanke om autismespektrumforstyrrelse (engelsk: ASD). Populationen er indsamlet på Børne- og Ungdomspsykiatrisk Regionscenter Risskov.

Programansvarlige

Professor, dr.med. Marlene Briciet Lauritsen. Forskningsenhed for Børne- og Ungdomspsykiatri, Aalborg Universitetshospital

Vejlederfunktioner

Vejledning kan foregå på mange niveauer fra f.eks. medicin- og psykologistuderende over kandidatstuderende til ph.d.-studerende.

Der er på nuværende tidspunkt udarbejdet et ph.d.-projekt under programmet, nemlig ”Outcome for adolescents and young adults diagnosed with autism spectrum disorder in childhood” af psykolog, ph.d. Ane Knüppel.

Samarbejdspartnere

I et igangværende projekt samarbejdes der med en forskergruppe fra University of Kentucky, USA under ledelse af Professor Lisa Ruble om data på en nyudviklet skala: Parent Empowerment, Activation, and Advocacy Scale.

Igangværende projekter

• Hvordan klarer personer med en autismespektrumforstyrrelse sig senere i livet?

   

• Hvad er forbruget af psykotrop medicin hos unge med ASF, der er diagnosticeret i barndommen?

   

• Occupational and academic outcome for adolescents and adults with autism. A systematic review.

   

• Risk of separation among parents of children with ADHD or ASD – a meta-analysis
  
  

• Risk of divorce among parents of children with ADHD and ASD – a register-based study

   

• Copy number variation findings among children suspected for having autism spectrum disorder

Kommende projekter

• Do children with autism have higher risk of developing psychotic disorders with age?

   

• Risk of substance use disorders among child and adolescent psychiatric patients

   

• Early onset schizophrenia, ADHD & autism: Comparative analyses of crime rates and crime types.

Månedens forskningsartikel fra april 2019

Udvalgte peer-reviewed publikationer fra afsluttede programprojekter

Knüppel, Ane; Telléus, Gry Kjaersdam; Jakobsen, Helle; Lauritsen, Marlene Briciet Characteristics of Young Adults with Autism Spectrum Disorder Performing Different Daytime Activities. J Autism Dev Disord.; 2019; 49(2):542-555

Knüppel A, Jakobsen H, Lauritsen MB, Telléus GK, Psychometric properties of the INICO-FEAPS scale in a Danish sample with autism spectrum disorders; Research in Developmental Disabilities 2018; 75:11-21.

Knüppel, A.; Telléus, G.K.; Lauritsen, M.B. Description of a Danish Nationwide Survey of Adolescents and Adults Diagnosed With Autism Spectrum Disorders in Childhood: The AutCome Study.

Journal of Mental Health Research in Intellectual Disabilities, 2018; 266-286.

Knüppel, Ane; Telléus, Gry Kjaersdam; Jakobsen, Helle; Lauritsen, Marlene Briciet Quality of life in adolescents and adults with autism spectrum disorder : Results from a nationwide Danish survey using self-reports and parental proxy-reports. Research in Developmental Disabilities; 2018; 83: 247-259.

Kousgaard SJ, Kjærgaard SB, Jensen CM, Lauritsen MB. The effect of having a child with ADHD or ASD on family separation. Social Psychiatry and Psychiatric Epidemiology 2018; 1391-1399

Lemcke, S, Parner, ET, Bjerrum, M, Thomsen, PH, Lauritsen, MB. Early regulation in children who are later diagnosed with autism spectrum disorder. A longitudinal study within the Danish national birth cohort. Infant mental health journal 2018; 39(2):170-182

Mahdi S,  Ronzano N,  Knüppel A,  Dias  JC,  Albdah A, Chien‑Ho L,  Almodayfer O, Bluschke A,  Karande S,  Huang H, Christiansen H, Granlund M, de Vries PJ,  Coghill D, Tannock R,  Rohde L, Bölte S;  An international clinical study of ability and disability in ADHD using the WHO‑ICF framework 2018; European Child and Adolescent Psychiatry 2018; 27, 1305-1319.

Mahdi S, Albertowski K, Almodayfer O,  Arsenopoulou M, Carucci S, Dias JC,  Khalil M, Knüppel A, Langmann A, Lauritsen MB, Rodrigues da Cunha G, Uchiyama T, Wolff N,  Selb M, Granlund M,  de Vries PJ, Zwaigenbaum L,  Bölte S; An International Clinical Study of Ability and Disability in Autism Spectrum Disorder Using the WHO-ICF Framework (2018) Journal of Autism and Developmental Disorders  2018; 48,2148-2163.

Frantzen KK, Lauritsen MB, Jørgensen M, Tanggaard L, Fetters MD, Aikens JE, Bjerrum M. Parental Self-perception in the Autism Spectrum Disorder Literature: a Systematic Mixed Studies Review. Review Journal of Autism and Developmental Disorders 2016; 3(1): 18-36.

Lemcke S, Parner ET, Bjerrum M, Thomsen PH, Lauritsen MB. Early Development in children that are later diagnosed with disorders of attention and activity. A longitudinal study in the Danish National Birth Cohort. European Child and Adolescent Psychiatry 2016; 25 (10): 1055-1066.

Salomone E, Beranová S, Bonnet-Brilhault F, Lauritsen MB, Bidisteanu M, Buitelaar J, Canal-Bedia R, Felhosi G, Fletcher-Watson S, Fuentes J, Gallagher L, Primo PG, Glige F, Gomot M, Green J, Heimann M, Jónsdóttir SL, Kaale A, Kawa R, Kylliainen A, Lemcke S, Markovska-Simoska S, Marschik PB, McConachie H, Moilanen I, Muratori F, Narzisi A, Noterdaeme M, Oliveira G, Oosterling I, Pijl M, Pop-Jordanova N, Poustka L, Roeyers H, Rogé B, Sinzig J, Vicente A, Warreyn P, Charman T. Use of early intervention for young children with autism spectrum disorders across Europe. Autism: The International Journal of Research and Practice 2016; 20(2): 233-249.

Steinhausen H-C, Jensen, CM, Lauritsen MB. A systematic review and meta-analysis of the long-term overall outcome of autism spectrum disorders in adolescence and adulthood. Acta Psychiatrica Scandinavica 2016; 133 (6) 445-452.

Jensen CM, Steinhausen H-C, Lauritsen MB. Time Trends Over 16 years in Incidence-Rates of Autism Spectrum Disorders Across the Lifespan Based on Nationwide Danish Register Data. Journal of Autism and Developmental Disorders 2014; 44(8): 1808-1818.

Lauritsen MB, Astrup A, Pedersen CB, Obel C, Schendel DE, Schieve L, Yeargin-Allsoff M, Parner ET. Urbanicity and Autism Spectrum Disorders. Journal of Autism and Developmental Disorders 2014; 44(2): 394-404.

Lemcke S, Juul S, Parner E, Lauritsen MB, Thorsen P. Early signs of autism in toddlers: a follow-up study in the Danish National Birth Cohort. Journal of Autism and Developmental Disorders 2013; 43(10): 2366-2375.