Forskningsprogrammet er etableret 1. januar 2016. Seneste opdatering 18.maj 2021.
Forskningsprogrammet retter sig mod at undersøge forekomst og betydning af somatisk og psykiatrisk co-morbiditet ved svære psykiatriske lidelser, samt udvikling af psykiatriske lidelser i befolkningen.
Udover udarbejdelse af originalarbejder rummer aktiviteterne udarbejdelse af oversigtsarbejder.
Programmet fokuserer på klinisk forskning i bred forstand, herunder også nationale registerprojekter. Deltagere i forsøg rekrutteres fra forskellige settings.
Programansvarlig
Professor, overlæge, ph.d. René Ernst Nielsen (ren@rn.dk).
René Ernst Nielsen primære forskningsinteresser er registerbaseret forskning i mortalitet og morbiditet ved svær psykiatrisk sygdom samt forskning i affektive sindslidelser. Han fungerer som vejleder for flere projekter under forskningsprogrammerne Affektive Sindslidelser og Mortalitet og Morbiditet ved Svær Psykiatrisk Sygdom. Ved siden af sine forskningsmæssige aktiviteter fungerer René Ernst Nielsen som overlæge i Psykiatrien, Region Nordjylland og varetager funktionen som assisterende redaktør på Nordic Journal of Psychiatry og BMC Psychiatry.
Vejlederfunktioner
Vejledning på alle niveauer, inklusiv ph.d.-niveau, og i alle projektfaser fra idefase til manuskriptfase.
Samarbejdspartnere
Internationalt
Christoph Correll, Zucker Hillside Hospital, Psychiatry Research, New York, USA; Hofstra North Shore LIJ School of Medicine, Hempstead, NY, USA
Mathias Zink, Zentralinstitut für Seelische Gesundheit, Klinik für Psychiatrie und Psychotherapie, Mannheim, Germany
Nationalt
Kjeld Andersen, Institute of Clinical Health, University of Southern Denmark, Department of Psychiatry, Odense, Region Syddanmark, Danmark
Annette Lolk, Institute of Clinical Health, University of Southern Denmark, Department of Psychiatry, Odense, Region Syddanmark, Danmark
Igangværende projekter
Mortality and morbidity in patients with Alzheimer’s dementia – a Danish nationwide 12- year register study
Projektleder: René Ernst Nielsen
Kontaktperson Aalborg: René Ernst Nielsen
Øvrige deltagere: Kjeld Andersen (Odense), Annette Lolk (Odense), Jan Brink Valentin (Aalborg), Maria Rodrigo Domingo (Aalborg).
Projektbeskrivelse: Formålet er at undersøge betydningen af kortvarig og langvarig antipsykotisk behandling samt betydningen af antidemens lægemidler på mortalitet generelt og på specifikke dødsårsager.
Projektstatus: Igangværende
Publikationsstatus:
RE Nielsen, A Lolk, JB Valentin, K Andersen. Cumulative dosages of antipsychotic drugs is associated with increased mortality-rate in patients with Alzheimer’s dementia. Acta Psychiatr Scand. 2016 Oct;134(4):314-20. doi: 10.1111/acps.12614. Epub 2016 Jun 30.
RE Nielsen, A Lolk, M Rodrigo-Domingo, JB Valentin, K Andersen. Antipsychotic treatment effects on cardiovascular, cancer, infection, and intentional self-harm as cause of death in patients with Alzheimer’s dementia. Accepted for publication. European Psychiatry. 2016.
Antipsychotic drug treatments effects on secular trends in all-cause-mortality in patients with Alzheimer’s dementia – a Danish nationwide 12- year register-based cohort study. RE Nielsen, JB Valentin, A Lolk, K Andersen. Accepted for publication. Journal of Clinical Psychiatry. 2017.
Real-world effects of anti-dementia treatment on mortality in patients with Alzheimer´s dementia (submitted)
How do symptoms correlate – A prospective study of incident patients diagnosed with schizophrenia
Projektledere: René Ernst Nielsen, Ditte Lammers Vernal
Kontaktperson Aalborg: René Ernst Nielsen, Ditte Lammers Vernal
Øvrige deltagere: Rikke Jørgensen (Aalborg), Mathias Zink (Mannheim), Christoph Correll (New York), Marlene Lauritsen (Aalborg).
Projektbeskrivelse: Prospektiv kohorte undersøgelse af patienter incidente for skizofreni i Region Nordjylland. Der foretages baseline-måling af symptomer, og der er planlagt en gentagelse af målingen efter 2 år.
Klinisk forankring i Region Nord: OPUS, Aalborg Universitetshospital, Psykiatrien
Projektstatus: Dataindsamling afsluttet.
Publikationsstatus: Dataanalyse er i gang
Mortality and morbidity in patients undergoing bariatric surgery
Projektleder: Zoltan Kovacs
Kontaktperson Aalborg: Zoltan Kovacs, René Ernst Nielsen
Øvrige deltagere: Jan Brink Valentin (Aalborg), Dalia Stakenaite (Aalborg)
Projektbeskrivelse: Undersøgelse af mortalitet og morbiditet hos patienter opereret for overvægt med gastric bypass operation.
Klinisk forankring i Region Nord: NA
Projektstatus: Data er indhentet og analyseret
Publikationsstatus:
Z Kovacs, JB Valentin, RE Nielsen. Psychiatric disorders, self-harm behavior, and service use, in patients undergoing bariatric surgery. Acta Psychiatr Scand. 2016 Nov 19. doi: 10.1111/acps.12669. [Epub ahead of print].
All-cause and specific cause mortality in patients undergoing bariatric surgery (submitted).
Trends and correlates of all-cause and specific-cause mortality in patients with severe psychiatric disorders
Projektleder: René Ernst Nielsen
Kontaktperson Aalborg: René Ernst Nielsen
Øvrige deltagere: Christoph Correll (New York), Maria Rodrigo Domingo (Aalborg)
Projektbeskrivelse: Formålet er at undersøge forskellige kendte risikofaktorers relative betydning for generel og specifik mortalitet hos patienter med svære psykiatriske lidelser.
Klinisk forankring i Region Nord: NA
Projektstatus: Data er indhentet og analysefase påbegyndt.
Publikationsstatus: Manuskript under udarbejdelse.
Mortality in schizophrenia, bipolar disorder and depression with early vs. adult onset - a Danish nationwide cohort-study investigating SMRs and standardized unnatural death rate ratios.
Projektleder: Ditte Lammers Vernal
Kontaktperson Aalborg: Ditte Lammers Vernal
Øvrige deltagere: Maria Rodrigo-Domingo, Marlene Briciet Lauritsen, René Ernst Nielsen
Projektbeskrivelse: Formålet er undersøge forskelle i mortalitetsrater ved psykiatriske tilstande sammenlignende diagnose i barndom/ungdom versus hos voksne
Klinisk forankring i Region Nord: NA
Projektstatus: Datagodkendelser foreligger. Analysefase er færdig.
Publikationsstatus: Manuskript er under udarbejdelse.
Risk of adverse events associated with psychotropic polypharmacy in patients with dementia
Projektleder: Johanne Købstrup Zakarias (Aalborg)
Kontaktperson Aalborg: René Ernst Nielsen
Øvrige deltagere: Ane Nørgaard (København), Christina Jensen-Dahm (København), Christiane Gasse (Aarhus), Thomas Laursen (Aarhus), Gunhild Waldemar (København)
Projektbeskrivelse: Formålet er undersøge forekomst af indlæggelse, hoftefrakturer og vaskulære outcomes hos patienter med demens eksponeret for psykotropika.
Projektstatus: Datagodkendelser foreligger. Analysefase er færdig.
Publikationsstatus: Manuskript er submitted.
Coronary artery disease as a cause of morbidity and mortality in patients suffering from schizophrenia
Projektleder: René Ernst Nielsen & Svend Eggert Jensen (Aalborg)
Kontaktperson: René Ernst Nielsen
Projektbeskrivelse: Formålet er undersøge forekomst af risikofaktorer for hjertekarsygdom i en kohorte af patienter som karakteriseres med psykometriske mål. Alle er diagnosticerede med skizofreni og der har været lavet baseline undersøgelse og på nuværende tidspunkt foregår opfølgning af samme patienter, ligesom der udarbejdes registerbasede undersøgelser og reviews.
Klinisk forankring i Region Nord: Psykiatrisk afdeling og kardiologisk afdeling, Aalborg Universitetshospital
Projektstatus: Dataindsamling pågår til opfølgning. Analyser pågår på baseline data.
Publikationsstatus: Under udarbejdelser.
Publiceret seneste 3 år:
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P Kugathasan, RE Nielsen. Somatik og overdødelighed hos patienter med skizofreni. Ugeskr Læger 2018; 180: V07170573
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P Kugathasan, TM Laursen, S Grøntved, SE Jensen, J Aagaard, RE Nielsen. Increased long-term mortality after myocardial infarction in patients with schizophrenia. Schizophr Res 2018 Sep; 199: 103-108
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P Kugathasan, HT Horsdal, J Aagaard, S Eggert Jensen, TM Laursen, RE Nielsen. Mortality and exposure to secondary preventive cardiovascular medications following myocardial infarction in patients with schizophrenia. JAMA Psychiatry. 2018 Dec 1;75(12):1234-1240
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P Kugathasan, M Berg Johansen, M Bak Jensen, J Aagaard, RE Nielsen, SE Jensen. Coronary artery calcification and mortality risk in patients with severe mental illness: A retrospective multicenter cohort study. Circ Cardiovasc Imaging 2019; 2
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Kugathasan P, Stubbs B, Aagaard J, Jensen SE, Laursen TM, Nielsen RE. Increased mortality from somatic multimorbidity in patients with schizophrenia: a Danish nationwide cohort study. Acta Psychiatr Scand 2019; 140: 340-348
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Kugathasan P, Wu H, Gaughran F, Nielsen RE, Pritchard M, Dobson R, Stewart R, Stubbs B. Association of physical health multimorbidity with mortality in people with schizophrenia spectrum disorders: Using a novel semantic search system that captures physical diseases in electronic patient records. Schizoph Res 2020; 216: 408-415
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Attar R, Jensen SE, Pedersen CT, Andell P, Nielsen RE, Kragholm K. Time trends in the use of coronary procedures, guideline-based therapy and all-cause mortality following acute coronary syndrome in patients with schizophrenia. Cardiology 2020; 145 (7): 401-409
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Trab T, Nielsen RE, Jensen SE. Relevans af koronarforkalkning for kardiovaskulær risikovurdering hos patienter med skizofreni. Ugeskr laeger 2020; 182 (31)
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Nielsen RE, Banner J, Jensen SE. Cardiovascular disease in patients with severe mental illness. Nat Rev Cardiol 2020; 18 (2): 136-145
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M Omar, C Polcwiartek, J Fleischer, JB Valenten, J Aagaard, SE Jensen, RE Nielsen. Cardiovascular Autonomic Neuropathy in Patients with Schizophrenia. Accepted for publication. Nordic Journal of Psychiatry. 2021.
Yderligere to manuskripter submittet og fem under udarbejdelse
Peer reviewed publikationer under forskningsprogrammet
RE Nielsen, A Lolk, JB Valentin, K Andersen. Cumulative dosages of antipsychotic drugs is associated with increased mortality-rate in patients with Alzheimer’s dementia. Acta Psychiatr Scand. 2016 Oct;134(4):314-20. doi: 10.1111/acps.12614. Epub 2016 Jun 30.
Z Kovacs, JB Valentin, RE Nielsen. Psychiatric disorders, self-harm behavior, and service use, in patients undergoing bariatric surgery. Acta Psychiatr Scand. 2017 Feb;135(2):149-158.
RE Nielsen, A Lolk, M Rodrigo-Domingo, JB Valentin, K Andersen. Antipsychotic treatment effects on cardiovascular, cancer, infection, and intentional self-harm as cause of death in patients with Alzheimer’s dementia. European Psychiatry. 2016 Dec 12;42:14-23. doi: 10.1016/j.eurpsy.2016.11.013. [Epub ahead of print]
P Kugathasan, RE Nielsen. Somatik og overdødelighed hos patienter med skizofreni. Ugeskr Læger2018; 180: V07170573
RE Nielsen, JB Valentin, A Lolk, K Andersen: Effects on antipsychotics on secular mortality trends in patients with Alzheimer´s Disease. Jo Clini Psych2018 May/Jun; 79(3) pii: 17m11595
P Kugathasan, TM Laursen, S Grøntved, SE Jensen, J Aagaard, RE Nielsen. Increased long-term mortality after myocardial infarction in patients with schizophrenia. Schizophr Res 2018 Sep; 199: 103-108
PS Hansen, MF Laursen, S Grøntved, SP Straszek, RW Licht, RE Nielsen. Increasing mortality gap for patients diagnosed with bipolar disorder – a nationwide study with twenty years of follow-up. Bipolar Disorders. 2018 Jul 26. doi: 10.1111/bdi.12684.
RE Nielsen, KB Hessellund, JB Valentin, RW Licht. Second-generation LAI are associated to favorable outcome in a cohort of incident patients diagnosed with schizophrenia. Schizophr Res 2018 Dec; 202:234-240
P Kugathasan, HT Horsdal, J Aagaard, S Eggert Jensen, TM Laursen, RE Nielsen. Mortality and exposure to secondary preventive cardiovascular medications following myocardial infarction in patients with schizophrenia. JAMA Psychiatry. 2018 Dec 1;75(12):1234-1240
RE Nielsen, RW Licht. Could we do more? Bipolar Disord 2018 Dec; 20(8): 683-684
LH Lomholt, DV Andersen, C Sejrsgaard-Jacobsen, CM Øzdemir, C Graff, O Schjerning, SPV Straszek, RW Licht, S Grøntved, RE Nielsen. Mortality rate trends in patients diagnosed with schizophrenia or bipolar disorder – a nationwide study with twenty years of follow-up. Int J Bipolar Disord 2019; 7: 6
P Kugathasan, M Berg Johansen, M Bak Jensen, J Aagaard, RE Nielsen, SE Jensen. Coronary artery calcification and mortality risk in patients with severe mental illness: A retrospective multicenter cohort study. Circ Cardiovasc Imaging 2019; 2
RE Nielsen, P Kugathasan, S Straszek, SE Jensen, RW Licht. Why are somatic diseases in bipolar disorder insufficiently treated? Int Bipolar Disord 2019; 7: 2
Kugathasan P, Stubbs B, Aagaard J, Jensen SE, Laursen TM, Nielsen RE. Increased mortality from somatic multimorbidity in patients with schizophrenia: a Danish nationwide cohort study. Acta Psychiatr Scand 2019; 140: 340-348
Kugathasan P, Wu H, Gaughran F, Nielsen RE, Pritchard M, Dobson R, Stewart R, Stubbs B. Association of physical health multimorbidity with mortality in people with schizophrenia spectrum disorders: Using a novel semantic search system that captures physical diseases in electronic patient records. Schizoph Res 2020; 216: 408-415
Attar R, Jensen SE, Pedersen CT, Andell P, Nielsen RE, Kragholm K. Time trends in the use of coronary procedures, guideline-based therapy and all-cause mortality following acute coronary syndrome in patients with schizophrenia. Cardiology 2020; 145 (7): 401-409
Trab T, Nielsen RE, Jensen SE. Relevans af koronarforkalkning for kardiovaskulær risikovurdering hos patienter med skizofreni. Ugeskr laeger 2020; 182 (31)
Nielsen RE, Banner J, Jensen SE. Cardiovascular disease in patients with severe mental illness. Nat Rev Cardiol 2020; 18 (2): 136-145
M Omar, C Polcwiartek, J Fleischer, JB Valenten, J Aagaard, SE Jensen, RE Nielsen. Cardiovascular Autonomic Neuropathy in Patients with Schizophrenia. Accepted for publication. Nordic Journal of Psychiatry. 2021.